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Promoter Methylation Status of E-Cadherin, hMLH1, and p16 Genes in Nonneoplastic Gastric Epithelia

✍ Scribed by Takayoshi Waki; Gen Tamura; Takashi Tsuchiya; Kiyoshi Sato; Satoshi Nishizuka; Teiichi Motoyama

Book ID
117022080
Publisher
American Society for Investigative Pathology
Year
2002
Tongue
English
Weight
166 KB
Volume
161
Category
Article
ISSN
0002-9440

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✍ Muthusamy Viswanathan; Nobuo Tsuchida; Govindaswamy Shanmugam πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 211 KB

## Abstract Aberrant promoter hypermethylation of tumor‐associated genes leading to their inactivation is a common event in many cancer types. Using a sensitive restriction‐multiplex PCR method, we studied the promoter hypermethylation profile of the __p16, p15, hMLH1, MGMT__ and __E‐cad__ genes in