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Gender Difference for Promoter Methylation Pattern of hMLH1 and p16 in Sporadic MSI Colorectal Cancer

✍ Scribed by Laghi, Luigi ;Bianchi, Paolo ;Malesci, Alberto

Book ID: 119757002
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 68 KB
Volume: 124
Category: Article
ISSN: 0016-5085
DOI: 10.1053/gast.2003.50199

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## Abstract Nonrandom, widespread promoter methylation of tumor suppressor genes is a common mechanism of gene inactivation during tumorigenesis. We examined the methylation status of two distinct regions of the __MLH1__ promoter (proximal and distal to the transcription start site) and the __MLH1_