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Methylation pattern of HMLH1 and microsatellite instability in sporadic colorectal cancers

โœ Scribed by Lage, Pedro A.; Cravo, Marilia L.; Maia, Lara; Claro, Isabel M.; Chaves, Paula P.; Albuquerque, Cristina M.; Gaspar, Claudia; Nobre-Leitao, Carlos A.


Book ID
122952696
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
295 KB
Volume
118
Category
Article
ISSN
0016-5085

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Distinct methylation pattern and microsa
โœ Hiromu Suzuki; Fumio Itoh; Minoru Toyota; Takefumi Kikuchi; Hideki Kakiuchi; Yuj ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 327 KB ๐Ÿ‘ 2 views

Aberrant 5ะˆ CpG island methylation is an alternative mechanism of gene inactivation during the development of cancer as demonstrated for several tumor-suppressor genes. Also, marked relationship of microsatellite instability (MSI) and DNA methylation has been reported in sporadic colorectal cancer,