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Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high-level microsatellite instability

โœ Scribed by Roberta A.U. Bevilacqua; Andrew J.G. Simpson

Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
66 KB
Volume
87
Category
Article
ISSN
0020-7136

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Methylation of the hMLH1 promoter in fam
Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability
โœ Yuka Yanagisawa; Yoshimitsu Akiyama; Satoru Iida; Emi Ito; Tadashi Nomizu; Kenic ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 128 KB ๐Ÿ‘ 1 views

Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i