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Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancers with microsatellite instability

โœ Scribed by Miyakura, Yasuyuki; Sugano, Kokichi; Akasu, Takayuki; Yoshida, Teruhiko; Maekawa, Masato; Saitoh, Soh; Sasaki, Hideyuki; Nomizu, Tadashi; Konishi, Fumio; Fujita, Shin


Book ID
122619948
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
393 KB
Volume
2
Category
Article
ISSN
1542-3565

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i