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Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer

โœ Scribed by Grady, William M.; Raiput, Ashwani; Lutterbaugh, James D.; Markowitz, Sanford D.


Book ID
124137640
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
179 KB
Volume
120
Category
Article
ISSN
0016-5085

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i