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Comprehensive analysis of promoter methylation and altered expression of hMLH1 in gastric cancer cell lines with microsatellite instability

✍ Scribed by Y.-H. Kang; S. Bae; W. Kim


Book ID
106123124
Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
201 KB
Volume
128
Category
Article
ISSN
1432-1335

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i