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Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability

โœ Scribed by Hwoon-Yong Jung; Kyeong Cheon Jung; Yhong Hee Shim; Jae Y. Ro; Gyeong Hoon Kang


Book ID
119740127
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
478 KB
Volume
51
Category
Article
ISSN
1320-5463

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Methylation of the hMLH1 promoter in fam
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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i