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Profile of methylated CpG sites of hMLH1 promoter in primary gastric carcinoma with microsatellite instability

โœ Scribed by Gyeong Hoon Kang; Sun Lee; Yhong Hee Shim; Jin Cheon Kim; Jae Y. Ro


Book ID
114431209
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
262 KB
Volume
52
Category
Article
ISSN
1320-5463

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i