๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

BRAF mutations and hMLH1 promoter methylation status in non-familial colorectal carcinoma with microsatellite instability

โœ Scribed by Koji Koinuma; Kazuhisa Shitoh; Yasuyuki Miyakura; Taiji Furukawa; Fumio Konishi; Yoshihiro Yamashita; Hideo Nagai; Hiroyuki Mano

Book ID
119427498
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
176 KB
Volume
124
Category
Article
ISSN
0016-5085

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Methylation of the hMLH1 promoter in fam
Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability
โœ Yuka Yanagisawa; Yoshimitsu Akiyama; Satoru Iida; Emi Ito; Tadashi Nomizu; Kenic ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 128 KB ๐Ÿ‘ 2 views

Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i

Mutations of BRAF are associated with ex
Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas
โœ Koji Koinuma; Kazuhisa Shitoh; Yasuyuki Miyakura; Taiji Furukawa; Yoshihiro Yama ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 175 KB ๐Ÿ‘ 2 views

## Abstract Activating mutations of __BRAF__ have been frequently observed in microsatellite unstable (MSI^+^) colorectal carcinomas (CRCs), in which mutations of __BRAF__ and __KRAS__ are mutually exclusive. Previously, we reported that hypermethylation of __hMLH1__ might play an important role in