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BRAF mutations mainly exist in microsatellite unstable sporadic colorectal cancer with methylated Hmlh1, but not in HNPCC

โœ Scribed by Guoren Deng; Ian Bell; Suzanne Crawley; James Gum; Jonathan P. Terdiman; Brian Allen; Marvin H. Sleisenger; Young S. Kim


Book ID
119427499
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
176 KB
Volume
124
Category
Article
ISSN
0016-5085

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Mutations of BRAF are associated with ex
โœ Koji Koinuma; Kazuhisa Shitoh; Yasuyuki Miyakura; Taiji Furukawa; Yoshihiro Yama ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 175 KB ๐Ÿ‘ 2 views

## Abstract Activating mutations of __BRAF__ have been frequently observed in microsatellite unstable (MSI^+^) colorectal carcinomas (CRCs), in which mutations of __BRAF__ and __KRAS__ are mutually exclusive. Previously, we reported that hypermethylation of __hMLH1__ might play an important role in