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Methylation of thehMLH1andhMSH2promoter in early-onset sporadic colorectal carcinomas with microsatellite instability

✍ Scribed by Hee C. Kim; Chang N. Kim; Chang S. Yu; Seon A. Roh; Jin C. Kim


Publisher
Springer
Year
2003
Tongue
English
Weight
282 KB
Volume
18
Category
Article
ISSN
0179-1958

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## Abstract Activating mutations of __BRAF__ have been frequently observed in microsatellite unstable (MSI^+^) colorectal carcinomas (CRCs), in which mutations of __BRAF__ and __KRAS__ are mutually exclusive. Previously, we reported that hypermethylation of __hMLH1__ might play an important role in