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Aberrant methylation of hMLH1 and p16INK4a in Tunisian patients with sporadic colorectal adenocarcinoma

✍ Scribed by Miladi‑Abdennadher, Imen; Abdelmaksoud‑Damak, Rania; Ayadi, Lobna; Khabir, Abdelmajid; Frikha, Foued; Kallel, Lamia; Frikha, Mounir; Sellami‑Boudawara, Tahia; Gargouri, Ali; Mokdad‑Gargouri, Raja

Book ID
120939451
Publisher
Springer
Year
2011
Tongue
English
Weight
340 KB
Volume
31
Category
Article
ISSN
0144-8463

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Hypermethylation of hMLH1, HPP1, p14ARF,
Hypermethylation of hMLH1, HPP1, p14ARF, p16INK4A and APC in primary adenocarcinomas of the small bowel
✍ Björn L.D.M. Brücher; Helene Geddert; Cord Langner; Heinz Höfler; Ulrich Fink; J 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 83 KB

## Abstract Small bowel adenocarcinoma (SB‐AC) is a very rare tumor entity. Epigenetic alterations, including hypermethylation of DNA mismatch repair genes and tumor suppressor genes, seem to be important for carcinogenesis in tumors of the gastrointestinal tract, but have not yet been investigated