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Reversible phosphorylation of 3-hydroxy-3-methylglutaryl CoA reductase in morris hepatomas

โœ Scribed by Ronald G. Gregg; Peter A. Wilce


Book ID
115756611
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
335 KB
Volume
114
Category
Article
ISSN
0006-291X

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Addition of hemoglobin, methemoglobin, hemin or hematin in the assay mixture of rat liver 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibited the activity of the enzyme. The inhibition by hemin was rapid, without any apparent dependence on time of preincubation. At 20 microM hemin, a maximum