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(3R,S)-3-hydroxy-3-methyl-4-carboxybutyl-CoA, a specific inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase

โœ Scribed by Tran-Giac Nguyen; Horst Aigner; Hermann Eggerer


Book ID
115912794
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
363 KB
Volume
128
Category
Article
ISSN
0014-5793

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Hemin-mediated oxidative inactivation of
โœ S. Usha Devi; T. Ramasarma ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer ๐ŸŒ English โš– 537 KB

Addition of hemoglobin, methemoglobin, hemin or hematin in the assay mixture of rat liver 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibited the activity of the enzyme. The inhibition by hemin was rapid, without any apparent dependence on time of preincubation. At 20 microM hemin, a maximum