๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

New site-directed reversible inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase

โœ Scribed by Bernhard SIXT; Hermann EGGERER


Book ID
115129053
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
630 KB
Volume
203
Category
Article
ISSN
1432-1327

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โœ S. Usha Devi; T. Ramasarma ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer ๐ŸŒ English โš– 537 KB

Addition of hemoglobin, methemoglobin, hemin or hematin in the assay mixture of rat liver 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibited the activity of the enzyme. The inhibition by hemin was rapid, without any apparent dependence on time of preincubation. At 20 microM hemin, a maximum