Hemin-mediated oxidative inactivation of
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S. Usha Devi; T. Ramasarma
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Article
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1987
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Springer
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English
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Addition of hemoglobin, methemoglobin, hemin or hematin in the assay mixture of rat liver 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibited the activity of the enzyme. The inhibition by hemin was rapid, without any apparent dependence on time of preincubation. At 20 microM hemin, a maximum