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Inactivation of soluble 3-hydroxy-3-methylglutaryl CoA reductase by ATP

โœ Scribed by F. Ursini; M. Valente; L. Ferri; C. Gregolin


Book ID
115907993
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
422 KB
Volume
82
Category
Article
ISSN
0014-5793

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Hemin-mediated oxidative inactivation of
โœ S. Usha Devi; T. Ramasarma ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer ๐ŸŒ English โš– 537 KB

Addition of hemoglobin, methemoglobin, hemin or hematin in the assay mixture of rat liver 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibited the activity of the enzyme. The inhibition by hemin was rapid, without any apparent dependence on time of preincubation. At 20 microM hemin, a maximum