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Inactivation of 3-hydroxy-3-methylglutaryl CoA reductase by Fe++ and a cytosolic protein

✍ Scribed by T. Ramasarma; Barbara Paton; S. Goldfarb


Book ID
119406988
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
322 KB
Volume
100
Category
Article
ISSN
0006-291X

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Hemin-mediated oxidative inactivation of
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Addition of hemoglobin, methemoglobin, hemin or hematin in the assay mixture of rat liver 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibited the activity of the enzyme. The inhibition by hemin was rapid, without any apparent dependence on time of preincubation. At 20 microM hemin, a maximum