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Stimulation of hepatic 3-hydroxy-3-methylglutaryl CoA reductase on administration of ATP

โœ Scribed by G.Subba Rao; Rajan George; T. Ramasarma


Book ID
118310089
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
193 KB
Volume
62
Category
Article
ISSN
0006-291X

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Hemin-mediated oxidative inactivation of
โœ S. Usha Devi; T. Ramasarma ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer ๐ŸŒ English โš– 537 KB

Addition of hemoglobin, methemoglobin, hemin or hematin in the assay mixture of rat liver 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibited the activity of the enzyme. The inhibition by hemin was rapid, without any apparent dependence on time of preincubation. At 20 microM hemin, a maximum