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Response: CALHM1 Association with Alzheimer's Disease Risk

✍ Scribed by Fabien Campagne; Jean-Charles Lambert; Ute Dreses-Werringloer; Valérie Vingtdeux; Corinne Lendon; Dominique Campion; Philippe Amouyel; Annette T. Lee; Peter K. Gregersen; Peter Davies; Philippe Marambaud


Book ID
116353959
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
89 KB
Volume
135
Category
Article
ISSN
0092-8674

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A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late-onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late-onset Alzheimer disease and 875 age-matched Caucasian American controls. No associatio

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A non-synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid beta accumulation. We aimed t