A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late-onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late-onset Alzheimer disease and 875 age-matched Caucasian American controls. No associatio
No Association between CALHM1 and Alzheimer's Disease Risk
β Scribed by Lars Bertram; Brit-Maren M. Schjeide; Basavaraj Hooli; Kristina Mullin; Mikko Hiltunen; Hilkka Soininen; Martin Ingelsson; Lars Lannfelt; Deborah Blacker; Rudolph E. Tanzi
- Book ID
- 116353958
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 82 KB
- Volume
- 135
- Category
- Article
- ISSN
- 0092-8674
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π SIMILAR VOLUMES
A non-synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid beta accumulation. We aimed t
## Abstract A number of studies suggest that brain cholesterol metabolism may play a role in Alzheimer's disease (AD) development, probably through modulation of amyloid beta production. The discovery that apolipoprotein E (__APOE__) Ξ΅4 allele is a risk factor for sporadic AD raises the possibility