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No Association between CALHM1 and Alzheimer's Disease Risk

✍ Scribed by Lars Bertram; Brit-Maren M. Schjeide; Basavaraj Hooli; Kristina Mullin; Mikko Hiltunen; Hilkka Soininen; Martin Ingelsson; Lars Lannfelt; Deborah Blacker; Rudolph E. Tanzi


Book ID
116353958
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
82 KB
Volume
135
Category
Article
ISSN
0092-8674

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No association between CALHM1 variation
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A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late-onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late-onset Alzheimer disease and 875 age-matched Caucasian American controls. No associatio

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A non-synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid beta accumulation. We aimed t

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## Abstract A number of studies suggest that brain cholesterol metabolism may play a role in Alzheimer's disease (AD) development, probably through modulation of amyloid beta production. The discovery that apolipoprotein E (__APOE__) Ξ΅4 allele is a risk factor for sporadic AD raises the possibility