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No association between CALHM1 and risk for Alzheimer dementia in a Belgian population

โœ Scribed by Kristel Sleegers; Nathalie Brouwers; Karolien Bettens; Sebastiaan Engelborghs; Helen van Miegroet; Peter P De Deyn; Christine Van Broeckhoven

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
121 KB
Volume
30
Category
Article
ISSN
1059-7794

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โœฆ Synopsis

A non-synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid beta accumulation. We aimed to investigate the association between this functional polymorphism and AD in an independent study population. We genotyped rs2986017 in 362 Belgian AD patients and 519 ethnically matched control individuals. We found no evidence of association between rs2986017 and risk of disease, nor did we find an effect on onset age. Despite its functional properties, our study suggests the polymorphism does not contribute significantly to AD risk in the Belgian population.

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