✦ LIBER ✦

No association between CALHM1 variation and risk of Alzheimer disease

✍ Scribed by Ryan L. Minster; F. Yesim Demirci; Steven T. DeKosky; M. Ilyas Kamboh

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 116 KB
Volume: 30
Category: Article
ISSN: 1059-7794
DOI: 10.1002/humu.20989

No coin nor oath required. For personal study only.

✦ Synopsis

A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late-onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late-onset Alzheimer disease and 875 age-matched Caucasian American controls. No association with risk of late-onset Alzheimer disease (p=0.368 for genotypes; p=0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age-at-onset was seen (p=0.034).

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