SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population
β Scribed by Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Peter P. De Deyn; Christine Van Broeckhoven; Kristel Sleegers
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 362 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1059-7794
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## Abstract Linkage studies have suggested a susceptibility locus for lateβonset Alzheimer's disease (LOAD) on chromosome 21. A functional candidate gene in this region is the Ξ²βamyloid precursor protein (APP) gene. Previously, coding mutations in APP have been associated with early onset Alzheimer