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SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population

✍ Scribed by Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Peter P. De Deyn; Christine Van Broeckhoven; Kristel Sleegers


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
362 KB
Volume
29
Category
Article
ISSN
1059-7794

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## Abstract Linkage studies have suggested a susceptibility locus for late‐onset Alzheimer's disease (LOAD) on chromosome 21. A functional candidate gene in this region is the β‐amyloid precursor protein (APP) gene. Previously, coding mutations in APP have been associated with early onset Alzheimer