Family with 22-derived marker chromosome and late-onset dementia of the Alzheimer type: I. Application of a new model for estimation of the risk of disease associated with the marker

Family with 22-derived marker chromosome

Family with 22-derived marker chromosome and late-onset dementia of the Alzheimer type: II. Further cytogenetic analysis of the marker and characterization of the high-level repeat sequences using fluorescence in situ hybridization

✍ Percy, Maire E. ;Dearie, Thomas G. ;Jabs, Ethylin Wang ;Bauer, Sharon J. ;Chodak 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 763 KB

## Abstract We have further characterized an unusual 22p+ marker chromosome with a double nucleolus organizer region (dNOR) previously identified in a family with late‐onset dementia of the Alzheimer type. G‐banding and morphology of the marker's q arm were typically normal. However, the p+ arm ha