Genetic Association Between CALHM1, 2 and 3 Polymorphisms and Alzheimer’s Disease in a Japanese Population
✍ Scribed by Nobuto Shibata; Borat Kuerban; Miwa Komatsu; Tohru Ohnuma; Hajime Baba; Heii Arai
- Book ID
- 118467408
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 59 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1552-5260
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A non-synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid beta accumulation. We aimed t
We investigated a common signal peptide polymorphism in the ␣ 1-antichymotrypsin (ACT) gene in 125 sporadic Alzheimer disease (AD) patients and 141 healthy control subjects in Chinese Han population. We found no significant difference in the distribution of ACT polymorphism between AD cases and cont