Resolution and absolute configuration of 7,12-dimethylbenz[a]anthracene 5,6-epoxide enantiomers
β Scribed by Mohammad Mushtaq; Henri B. Weems; Shen K. Yang
- Book ID
- 115757493
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 431 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0006-291X
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The absolute configurations of enantiomeric 7-bromo-12lpethylbenz[a]anthracene cis 5,6-dihydrodiols (3) were determined by exciton chirality circular dichroism method, The absolute configurations of enantiomeric 12-methylbenz[a]anthracene c&-5,6-dihydrodiols (1) were determined by debromination of e
## Abstract Female SpragueβDawley rats were given a subcutaneous injection of the parent hydrocarbon or its Kβregion epoxide in 0.1 ml sesame oil on alternate days to a total of 30 doses and observed for sarcoma at the site of injection for 275 days. The parent compounds, benzo(a)__pyrene (0.2 ΞΌmol
Column chromatography and electron-capture gas chromatography have been applied to the separation and quantitative analysis of the K-region epoxide of 7,12-dimethylbenz(a)anthracene, S-hydroxy-7,12-dimethylbenz(a)anthracene, and trans-5,6-dihydro-5,6-dihydroxy-7,12-dimethylbenz(a)anthracene. Deacti