Specificity of cDNA-expressed human and
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Magang Shou; Kenneth R. Korzekwa; Kristopher W. Krausz; Jeroen T. M. Buters; Jam
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Article
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1996
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John Wiley and Sons
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English
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7,12-Dimethylbenz[a]anthracene (DMBA), a potent carcinogen, requires metabolic activation by cytochrome P450s (P450s) t o electrophilic metabolites that result in DNA modification, mutagenicity, and carcinogenicity. In this study, we used eight human forms, four rodent forms, and one rabbit form of