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Absolute configuration of the 5,6-oxide formed from 7,12-dimethylbenz[a]anthracene by cytochrome P450c

โœ Scribed by Suresh K. Balani; Herman J.C. Yeh; Dene E. Ryan; Paul E. Thomas; Wayne Levin; Donald M. Jerina


Book ID
115758474
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
461 KB
Volume
130
Category
Article
ISSN
0006-291X

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7,12-Dimethylbenz[a]anthracene (DMBA), a potent carcinogen, requires metabolic activation by cytochrome P450s (P450s) t o electrophilic metabolites that result in DNA modification, mutagenicity, and carcinogenicity. In this study, we used eight human forms, four rodent forms, and one rabbit form of