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Oncogenicity of k-region epoxides of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene

✍ Scribed by James W. Flesher; Ronald G. Harvey; Katherine L. Sydnor

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
252 KB
Volume
18
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Female Sprague‐Dawley rats were given a subcutaneous injection of the parent hydrocarbon or its K‐region epoxide in 0.1 ml sesame oil on alternate days to a total of 30 doses and observed for sarcoma at the site of injection for 275 days. The parent compounds, benzo(a)pyrene (0.2 μmole/dose) and 7,12‐dimethylbenz(a)anthracene (0.2 μmole/dose), induced sarcoma in 100% of the animals with an average latent period of 101 and 95 days, respectively, whereas five of 12 rats (42%) injected with the K‐region epoxide of B(a)P (1.0 μmole/dose), developed sarcoma in 151±22 days, and the K‐region epoxide of DMBA (0.4 μmole/dose) failed to elicit tumors. Under these experimental conditions, these K‐region epoxides are, at best, only weak carcinogens.

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