✦ LIBER ✦

Disposition kinetics of 7,12-dimethylbenz(a)anthracene in rats

✍ Scribed by Dr Sarfaraz K. Niazi; Musarrat Hussain

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 345 KB
Volume: 13
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510130805

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

One of the most potent carcinogens is 7,12‐dimethylbenz(a)anthracene (7,12‐DMBA), which is used routinely to conduct studies to evaluate carcinogen inhibitors. Its pharmacokinetics have not been reported in the literature. In view of its significant effects on drug metabolizing enzymes and clearance mechanisms, it is important to know its disposition characteristics. In this study, we monitored the disposition characteristics of 7,12‐DMBA in rats as a function of dose range commonly used in carcinogenesis studies. A mean residence time of 40–55 min was observed; the total body clearance ranged from 8–13 1 kg^−1^. No effect of dose was observed on the pharmacokinetic parameters. This suggests that the dose‐dependent effects of 7,12‐DMBA carcinogenesis are related to its transient disposition characteristics.

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