Mutant frequency and molecular analysis of in vivo lacI mutations in the bone marrow of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene

Comparison of the types of mutations ind

Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue® rats

✍ Roberta A. Mittelstaedt; Mugimane G. Manjanatha; Sharon D. Shelton; Lascelles E. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 1 views

An important question regarding the use of transgenic reporter genes to detect mutation in rodents is how the types of mutations recovered in transgenes compare with the types of mutations found in endogenous genes. In this study, we examined mutations induced by 7,12-dimethylbenz[a]anthracene in th