## Abstract Female Sprague‐Dawley rats were given a subcutaneous injection of the parent hydrocarbon or its K‐region epoxide in 0.1 ml sesame oil on alternate days to a total of 30 doses and observed for sarcoma at the site of injection for 275 days. The parent compounds, benzo(a)__pyrene (0.2 μmol
Mass spectral characterization of the K-region and non K-region dihydrodiols of 7,12-dimethylbenz(a)anthracene
✍ Scribed by Lan K. Wong; Chih-Lueh A. Wang; F. Bernard Daniel
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 364 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1076-5174
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Methanolysis of the K-region epoxide of 7,12-dimethylbenz (a) anthracene (DMBA) gave rise to two hydroxy-methoxy derivatives which were dehydrated to S-methoxy-DMBA and 6-methoxy-DMBA at a ratio of 5: 1. The data indicate that methanol attacks preferentially at the 5-position of the arene oxide. The
## Abstract K‐region epoxides derived from 7, 12‐dimethylbenz(a)anthracene and from 7‐hydroxymethlybenz(a)anthracene were tested for their ability to induce malignant transformation of the M2 clone of fibroblasts derived from C3H mouse prostate. The parent hydrocarbons, the corresponding K‐region d
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