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Radioactively labelled epoxides. part V. Tritium labelled K-region oxides and trans-dihydrodiols of pyrene, benzo[a]pyrene and dibenz[a, h]anthracene

✍ Scribed by Frans Setiabudi; Franz Oesch; Karl L. Platt


Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
296 KB
Volume
24
Category
Article
ISSN
0022-2135

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✦ Synopsis


T r i t i u m l a b e l l e d K-region oxides o f pyrene, benzoCalpyrene and d i b e n z [ G ] a n t h r a c e n e have been prepared by c y c l i z a t i o n o f the corresponding t r a n s -d i h y d r o d i o l s which were obtained by r e d u c t i o n o f K-region quinones w i t h sodium b o r o t r i t i d e i n t h e presence o f oxygen. This s y n t h e t i c pathway n o t o n l y y i e l d s two m e t a b o l i c a l l y important r a d i o a c t i v e l y l a b e l l e d d e r i v a t i v e s o f p o l y c y c l i c aromat i c hydrocarbons i n a simple