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Regional myocardial oxygen tension: 19F MRI of sequestered perfluorocarbon

✍ Scribed by Himu P. Shukla; Ralph P. Mason; Navin Bansal; Peter P. Antich

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
693 KB
Volume
35
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A novel noninvasive method of measuring local myocardial oxygen tension (pO~2~) In the perfused rat heart using ^19^F MRI is demonstrated. Tissue pO~2~ was determined on the basis of the ^19^F spin‐lattice relaxation rate (R1) of perflubron (perfluorooctyl bromide) sequestered in the heart after IV infusion of an emulsion. Spectroscopic measurement of R1 was previously used to measure a global weighted average of oxygen status. ^19^F MRI now provides 3D spatial resolution indicating local cardiac pO~2~ under normally perfused, globally ischemic, and regionally ischemic conditions.

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