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Oxygen tension mapping with F-19 echo-planar MR imaging of sequestered perfluorocarbon

✍ Scribed by Bruce R. Barker; Ralph P. Mason; Navin Bansal; Ronald M. Peshock

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
913 KB
Volume
4
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

The authors used fluorine‐19 inversion‐recovery (IR) echo‐planar imaging (EPI) to map oxygen tension on the basis of the spin‐lattice relaxation rate (R1) of sequestered perfluorocarbon. R1 measured with IR‐EPI varied as a linear function of oxygen tension and temperature, and the relationship agreed well with earlier spectroscopic findings. Oxygen tension maps of a mouse that had received a dose of perflubron emulsion were acquired before, during, and after the mouse breathed pure oxygen. Results showed low liver oxygen tension during air breathing, which increased during breathing of pure oxygen, with distinct regional heterogeneity, to 8–17%atm (60–130 torr [8.0–17.3 kPa]).

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