Application of a 3D volume 19FMR imaging protocol for mapping oxygen tension (pO2) in perfluorocarbons at low field
✍ Scribed by Ronald G. Pratt; Jie Zheng; Brent K. Stewart; Yoseph Shiferaw; Anthony J. McGoron; Ranasinghage C. Samaratunga; Stephen R. Thomas
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 762 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A limited flip angle gradient‐echo 3D volume acquisition imaging protocol for mapping partial pressure of oxygen (pO~2~) in perfluorocarbon compounds (PFCs) at low field (0.14 T) is presented. The pO~2~ measurement method is based on the paramagnetic effect of dissolved molecular oxygen (O~2~) which reduces the PFC ^19^F T~1−~ Specific objectives related to imaging of PFCs through use of the protocol include improved image signal‐to‐noise characteristics and elimination of ^19^F chemical shift artifacts. A parametric Wiener deconvolution filtering algorithm is used for suppression of ^19^F chemical shift artifacts. Application of the protocol is illustrated in a series of calculated pO~2~ maps of a gas equilibrated, multi‐chamber phantom containing perfluorotributylamine (FC‐43). The utility of the protocol is demonstrated in vivo through images of a commercially available perfluorocarbon based blood substitute emulsion containing FC‐43 sequestered in the liver and spleen of a rat.