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A noninvasive assessment of myocardial oxygen tension: 19f nmr spectroscopy of sequestered perfluorocarbon emulsion

✍ Scribed by Ralph P. Mason; F. Mark H. Jeffrey; Craig R. Malloy; Evelyn E. Babcock; Peter P. Antich

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
468 KB
Volume
27
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Fluorine NMR spectroscopy of sequestered perfluorocarbon emulsion has been used to measure myocardial oxygen tension. This novel application provides a rapid noninvasive assessment of changes in oxygen tension in response to ischemia and reperfusion. Rats were predosed with Oxypherol‐ET (emulsion of perfluorotributylamine). Following vascular clearance of the emulsion the heart was excised and perfused using the Langendorff retrogradetechnique. ^19^F spin‐lattice relaxation time measurements provided an accurate estimate of myocardial __p__O~2~. Using a two‐point determination with a time resolution of 1 s, the loss of oxygen was found to be complete within 40 s of the onset of global ischemia. The fall in oxygen tension correlated closely with an observed loss of ventricular pressure. Magnetic resonance imaging showed that perfluorocarbon was distributed throughout the heart; thus, this reporter molecule provides a global measurement of oxygen tension.

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