Refined characterization of head and neck squamous cell carcinomas expressing a seemingly wild-type p53 protein
β Scribed by Katharina Leng; Simone Schlien; Franz X. Bosch
- Book ID
- 111254887
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 193 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0904-2512
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π SIMILAR VOLUMES
Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of functional aberration has been demonstrated. In this
Loss of wild-type p53, either through deletion or mutation, has been demonstrated in most squamous cell carcinomas of the head and neck (HNSCC). Whether these mutant molecules contribute to tumor progression purely through loss of wild-type functions or by growth-promoting mechanisms, however, remai
## Abstract ## Objectives This study aims at investigating the prognostic values of serum p53 protein and antiβp53 antibody in patients undergoing surgical treatment for head and neck squamous cell carcinoma (HNSCC). ## Methods Serum p53 protein and antiβp53 antibody concentrations were determin