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Refined characterization of head and neck squamous cell carcinomas expressing a seemingly wild-type p53 protein

✍ Scribed by Katharina Leng; Simone Schlien; Franz X. Bosch


Book ID
111254887
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
193 KB
Volume
35
Category
Article
ISSN
0904-2512

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Functional characterization of p53 molec
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Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of functional aberration has been demonstrated. In this

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Loss of wild-type p53, either through deletion or mutation, has been demonstrated in most squamous cell carcinomas of the head and neck (HNSCC). Whether these mutant molecules contribute to tumor progression purely through loss of wild-type functions or by growth-promoting mechanisms, however, remai

Prognostic significance of serum p53 pro
✍ Vivian Chow; Anthony Po Wing Yuen; King Yin Lam; Wai Kuen Ho; William Ignace Wei πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 79 KB πŸ‘ 1 views

## Abstract ## Objectives This study aims at investigating the prognostic values of serum p53 protein and anti‐p53 antibody in patients undergoing surgical treatment for head and neck squamous cell carcinoma (HNSCC). ## Methods Serum p53 protein and anti‐p53 antibody concentrations were determin