✦ LIBER ✦

Prognostic significance of serum p53 protein and p53 antibody in patients with surgical treatment for head and neck squamous cell carcinoma

✍ Scribed by Vivian Chow; Anthony Po Wing Yuen; King Yin Lam; Wai Kuen Ho; William Ignace Wei

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 79 KB
Volume: 23
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.1032

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objectives

This study aims at investigating the prognostic values of serum p53 protein and anti‐p53 antibody in patients undergoing surgical treatment for head and neck squamous cell carcinoma (HNSCC).

Methods

Serum p53 protein and anti‐p53 antibody concentrations were determined by an enzyme‐linked immunosorbent assay (ELISA) in 75 patients with HNSCC and 28 healthy controls. In 28 patients, formalin‐fixed tumor tissues were also available for immunohistochemical staining by an anti‐p53 DO7 monoclonal antibody. The results were correlated with the clinicopathologic parameters.

Results

The mean preoperative serum concentration of p53 protein in patients with HNSCC was significantly higher than healthy controls (59.45 pg/mL vs 16.4 pg/mL, p = .007). Preoperative serum p53 antibody was present in 23 (31%) patients and was present in one healthy control. Eighteen (62%) tumor tissues showed p53 overexpression by immunohistochemistry. The presence of serum anti‐p53 antibody before operation was associated with a significantly higher incidence (65%) of nodal metastasis compared with 27% nodal metastasis in patients with absence of serum anti‐p53 antibody (p = .002).

Conclusion

📜 SIMILAR VOLUMES

Prognostic significance of serum p53 ant

Prognostic significance of serum p53 antibodies in patients with limited-stage small cell lung cancer

✍ Gérard Zalcman; Jean Trédaniel; Beata Schlichtholz; Thierry Urban; Bernard Mille 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 239 KB 👁 2 views

p53 tumour suppressor gene alterations are one of the most frequent genetic events in lung cancer. A subset of patients with p53 mutation and cancer exhibited circulating serum anti-p53 self-antibodies (p53-Ab). The prevalence of these antibodies in lung cancer is currently being analysed in a multi

P53 mutation correlates with cisplatin s

P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines

✍ Carol R. Bradford; Shaobo Zhu; Haruko Ogawa; Tetsuya Ogawa; Matthew Ubell; Ajita 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB 👁 2 views

## Background: A critical factor for successful organ preservation treatment in head and neck cancer may be selecting tumors that respond to chemotherapy and radiation. previous results in patients indicated that tumors that overexpressed p53 were more sensitive to chemotherapy than those that did

Prognostic significance of Bcl-2 and p53

Prognostic significance of Bcl-2 and p53 expression in advanced laryngeal squamous cell carcinoma

✍ Michael Friedman; Jessica W. Lim; Ernie Manders; Adam D. Schaffner; Gary L. Kirs 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 79 KB 👁 1 views

## Abstract ## Background Proteins regulating the cell cycle and cell death are frequently abnormally expressed in cancer. Several of these, particularly p53 and Bcl‐2, have been widely suggested as possible prognostic markers in diverse human malignancies. Their role in predicting outcome in squa

Loss of heterozygosity at 9p and p53 imm

Loss of heterozygosity at 9p and p53 immunopositivity in surgical margins predict local relapse in head and neck squamous cell carcinoma

✍ A. Peggy Graveland; Pawel J. Golusinski; Marijke Buijze; Rinze Douma; Nanet Sons 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 317 KB 👁 1 views

## Abstract A major problem in head and neck cancer surgery is the high rate of local relapse (LR). In at least 25% of the surgically treated head and neck squamous cell carcinoma (HNSCC) patients, a genetically defined preneoplastic lesion, also known as “field,” can be detected in the surgical ma

Clinical significance of serum p53 antib

Clinical significance of serum p53 antibodies in patients with ulcerative colitis and its carcinogenesis

✍ Shigeo Yoshizawa; Katsuyoshi Matsuoka; Nagamu Inoue; Hiromasa Takaishi; Haruhiko 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 1 views

## Background: For early detection of ulcerative colitis (uc)-associated colorectal cancer (crc), surveillance colonoscopy is recommended in uc patients at high risk. however, poor acceptability deteriorates its effectiveness and a suitable marker for selecting patients at high risk is needed. here

Functional characterization of p53 molec

Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck

✍ W. Andrew Yeudall; Judit Jakus; John F. Ensley; Keith C. Robbins 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 2 views

Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of functional aberration has been demonstrated. In this