p53 mutations in relation to human papillomavirus type 16 infection in squamous cell carcinomas of the head and neck
โ Scribed by Andrea G.M. Scholes; Triantafillos Liloglou; Peter J.F. Snijders; C. Anthony Hart; Andrew S. Jones; Julia A. Woolgar; E. David Vaughan; Jan M.M. Walboomers; John K. Field
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 66 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0020-7136
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Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of functional aberration has been demonstrated. In this
## RESULTS. DO7, an anti-p53 monoclonal antibody, showed p53 overexpression in 35 carcinomas (53%). Consensus primer PCR showed HPV infection in 12 carcinomas
Human papillomaviruses (HPVs) have been recognized as an essential pathogenic factor in anogenital cancer. HPV DNA has also been found in a subgroup of head-and-neck squamous-cell carcinomas (HNSCCs), and a causative role of the virus in the development of these tumors has been suggested by the conc
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Loss of wild-type p53, either through deletion or mutation, has been demonstrated in most squamous cell carcinomas of the head and neck (HNSCC). Whether these mutant molecules contribute to tumor progression purely through loss of wild-type functions or by growth-promoting mechanisms, however, remai