Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of functional aberration has been demonstrated. In this
p53 Expression and cell proliferation in squamous cell carcinomas of the head and neck
✍ Scribed by Karin Nylander; Roger Stenling; Hans Gustafsson; Björn Zackrisson; Göran Roos
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 879 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Background. There is considerable interest in the expression of cancer testis (CT) antigens in human cancers, because they may serve as the basis for diagnostic tests or an immunologic approach to therapy, or as prognostic markers. ## Methods. On this basis, we evaluated by semiqu
## Abstract ## Background Niban was initially identified in the Eker rat, a model of renal carcinogenesis. We examined Niban expression in head and neck squamous cell carcinoma (HNSCC) and head and neck dysplastic lesions. ## Methods Using a polyclonal rabbit anti‐human Niban antibody, 43 cases
## Background: Squamous cell carcinoma (scc) of the head and neck region is rare in young patients and even less frequent in children 15 years or younger children. the patients reported in the literature are isolated cases and their management is always difficult because there is no large experienc
## Background: Serine proteases have important roles in tumor invasion and metastasis, and their inhibitors, serine protease inhibitors (serpins), are attractive targets for therapeutic strategies. on chromosome 18q21, there is a cluster of serpins: maspin, headpin, and squamous cell carcinoma anti
## Background: A critical factor for successful organ preservation treatment in head and neck cancer may be selecting tumors that respond to chemotherapy and radiation. previous results in patients indicated that tumors that overexpressed p53 were more sensitive to chemotherapy than those that did