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Reductive amination of [18F]fluorobenzaldehydes: Radiosyntheses of [2-18F]- and [4-18F]fluorodexetimides

✍ Scribed by Alan A. Wilson; Robert F. Dannals; Hayden T. Ravert; Henry N. Wagner Jr.

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
458 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Two [^18^F]‐labelled analogues of dexetimide, a potent muscarinic cholinergic receptor ligand, have been synthesised in good yields and at high specific activities. Reductive amination of [2‐^18^F]‐ and [4‐^18^F]fluorobenzaldehyde with norbenzyldexetimide and sodium cyanoborohydride gave, in a one‐pot reaction, good (≈︁20%) yields of high specific activity [2‐^18^F]‐ and [4‐^18^F]fluorodexetimide respectively. The labelled benzaldehydes may be useful synthetic precursors for the radiosyntheses of other complex radiotracers for use with positron emission tomography.

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