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Radiosynthesis of 3-[18F]fluoropropyl and 4-[18F]fluorobenzyl triarylphosphonium ions

✍ Scribed by Hayden T. Ravert; Igal Madar; Robert F. Dannals

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
98 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

3‐[^18^F]Fluoropropyl‐, 4‐[^18^F]fluorobenzyl‐triphenylphosphonium and 4‐[^18^F]fluorobenzyltris‐4‐dimethylaminophenylphosphonium cations were synthesized in multi‐step reactions from no carrier added (nca) [^18^F]fluoride. The time for synthesis, purification, and formulation was 56, 82, and 79 min with an average radiochemical yield of 12, 6 and 15%, respectively (not corrected for decay). The average specific radioactivity for the three radiolabeled compounds was 14.9 GB q/µmole (403 mCi/µmole) at end of synthesis (EOS). Copyright © 2004 John Wiley & Sons, Ltd.

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