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Two-step radiosynthesis of [18F]N-succinimidyl-4-fluorobenzoate ([18F]SFB)

✍ Scribed by Matthias Glaser; Erik Årstad; Sajinder K. Luthra; Edward G. Robins

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
141 KB
Volume
52
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The acylation reagent [^18^F]N‐succinimidyl‐4‐fluorobenzoate (^18^F‐SFB) has been prepared using a new two‐step approach. The starting material p‐[^18^F]fluorobenzaldehyde (^18^F‐FBA) was obtained by an improved radiosynthesis with a decay‐corrected radiochemical yield of 66±6 % (n=3). Reaction of ^18^F‐FBA with (diacetoxyiodine)benzene and N‐hydroxysuccinimide and preparative HPLC purification furnished ^18^F‐SFB in an r.c.y. of 49±6 % (n=3), based on the starting radioactivity of ^18^F‐FBA. The radiochemical purity of ^18^F‐SFB was >99%. Alternatively, purification by solid phase extraction gave ^18^F‐SFB with an r.c.y. of 77±9% (n=4) and a radiochemical purity of 89±5% (n=4). This radiochemical synthesis only used non‐aqueous solvents, which simplifies the method and facilitates subsequent applications of ^18^F‐SFB. Copyright © 2009 John Wiley & Sons, Ltd.

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