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Utility of azetidinium methanesulfonates for radiosynthesis of 3-[18F]fluoropropyl amines

✍ Scribed by Dale O. Kiesewetter; William C. Eckelman

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
154 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

3‐Methanesulfonyloxypropyl tertiary amines were observed to cyclize to form azetidinium methanesulfonate moieties. Heat‐induced cyclization of 3‐methanesulfonyloxypropyl amines was utilized for preparation of azetidinium methanesulfonates. The azetidinium methanesulfonates were found to incorporate radioactive [^18^F]fluoride (decay‐corrected yields >60%) efficiently, resulting in an efficient synthesis of 3‐[^18^F]fluoropropyl tertiary amines. Copyright © 2004 John Wiley & Sons, Ltd.

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