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Synthesis of N1-3-[18F]fluoropropyl-N4-2-([3,4-dichlorophenyl]ethyl)piperazine, a high affinity ligand for sigma receptor

✍ Scribed by Dale O. Kiesewetter; Brian de Costa

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
275 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The radiochemical synthesis of the high affinity, selective sigma receptor ligand, N^1^‐3‐[^18^F]Fluoropropyl‐N^4^‐2‐([3,4‐dichlorophenyl]ethyl)piperazine, is reported. The labeled compound is prepared by fluoride displacement on a bismethanesulfonate salt of the propyl methanesulfonyloxy precursor. The product is isolated by first passage through a BONDELUT‐SI and subsequently HPLC in high radiochemical and chemical purity with a decay corrected radiochemical yield of 49 ± 9%.

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