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Hydroacylation of 4-[18F]fluorobenzaldehyde: a novel method for the preparation of 4′-[18F]phenylketones

✍ Scribed by Noor-Ul Hasan Khan; Byung Chul Lee; Sang-Yoon Lee; Yearn Seong Choe; Chul-Ho Jun; Dae Yoon Chi

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
101 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

To assess the potential of intermolecular hydroacylation reactions as a new fluorine‐18 labeling method, model reactions of [^18^F]fluorobenzaldehyde with three different olefins (1‐hexene (2a), allylbenzene (2b), and 3‐phenoxypropene (2c)) in the presence of Wilkinson's catalyst were performed. The procedure gave high radiochemical yields (38–62%) of [^18^F]fluorophenylketones with short reaction times (15 min). The intermolecular hydroacylation reaction provides a new method for the preparation of fluorine‐18 labeled compounds. Copyright © 2002 John Wiley & Sons, Ltd.

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