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Recommendation for a practical production of [2-18F]fluoro-2-deoxy-D-glucose

✍ Scribed by H.H. Coenen; V.W. Pike; G. Stöcklin; R. Wagner

Publisher
Elsevier Science
Year
1987
Weight
569 KB
Volume
38
Category
Article
ISSN
0883-2889

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Labeled 2-deoxy-D-glucose analogs. 18F-l
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## Abstract A convenient method for the synthesis of ^18^F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and ^18^F‐2‐deoxy‐2‐fluoro‐D‐mannose (8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with ^18^F‐F~2~ is described. ^14^C‐2‐deoxy‐2‐fluoro‐D‐glucose has been synthesized from ^14^C‐3,4,6‐tri‐0‐ace

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A combined study of the labelling methods of two important glucose-derivatives i.e. [18F]2-deoxy-2-fluoro-D-glucose ([laF]2-FDG) and [lSF]3-deoxy-3-fluoro-D-glucose ([18F]3-FDG) is described. Using [ISF]fluoride as reacting agent produced in a water target via the 180(p, n)'SF and ~60(3He, p)~SF rea