Reaktionen ionisierter 4-Benzyl-2-methyl-1,2,3,4-tetrahydroisochinoline in der Gasphase
✍ Scribed by Gerd Dannhardt; Josef Kiermaier; Klaus K. Mayer; Julius Roelcke
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 533 KB
- Volume
- 325
- Category
- Article
- ISSN
- 0365-6233
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**A new Synthesis of 8‐Hydroxy‐2‐methyl‐1,2,3,4‐tetrahydroisoquinoline** __Vilsmeier__ formylation of __N__‐[2‐(3,5‐dimethoxyphenyl)ethyl]‐trifluoroacetamide (**5**) yielded the aldehyde **6**, which under mild basic conditions was hydrolyzed to **7** and cyclized to 6,8‐dimethoxy‐3,4‐dihydroisoqui
## Abstract Hofmann exhaustive methylation of the analgesic 1‐__p__‐chlorophenethyl‐2‐methyl‐6,7‐dimethoxy‐1,2,3,4‐tetrahydro‐isoquinoline (Versidyne = I) leads to 1‐dimethylamino‐1‐(2′‐vinyl‐4′,5′‐dimethoxy‐phenyl)‐3‐(__p__‐chloro‐phenyl)‐propane (III), the only product formed. Its structure was p