Reaction of [18F]acetyl hypofluorite with derivatives of dihydroxyphenylalanine: Synthesis of l-[18F]6-fluorodopa
β Scribed by Michael J. Adam; John R. Grierson; Thomas J. Ruth; Salma Jivan
- Publisher
- Elsevier Science
- Year
- 1986
- Weight
- 393 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0883-2889
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
This work describes the synthesis and purification of L-6-["Fjfluorodopa synthesized via the reaction of acetyl hypofluorite with a mercury-dopa derivative. The mercurated starting material and the mercury compounds produced in the reaction are efficiently removed by passage of the reaction mixture
The fluorination of the antitumour agents VP 16-213 and podophyllotoxin using ['sF]acetyl hypofluorite is described. Overall labeling yields of 10% and 20% respectively were obtained. The F-atom is found to be introduced into the E-moiety of the compounds, apparently without unwanted conformational
## Abstract 3βOβMethylβ6β[^18^F]fluorodopa was synthesized in 20% radiochemical yield in 60 min, with a specific activity of 500 mCi/mmol, by the fluorination of a stannylated dopa precursor with [^18^F]βacetyl hypofluorite.
## Abstract 3βOβMethylβ2β and 6β[^18^F]βfluorodopa were synthesized in 8% radiochemical yield by the direct fluorination of a protected Lβdopa derivative with [^18^F]βacetyl hypofluorite. The 2β and 6βfluoro isomers were separated and purified by reverse phase HPLC.